Battle of the Botox: Botox Cosmetic™ vs. Dysport®

Move over Botox Cosmetic™ , there’s a new wrinkle fighter in town!  Approved in Spring 2009,  Dysport® was recently made available in the US through Medicis, the company that manufactures Restylane.  Dysport has been approved and used all over Europe and Asia for ten years to prevent wrinkles, and showed significant clinical safety and efficacy. Only recently has it made is way into clinics here in the US.

So what’s the difference between Botox Cosmetic and Dysport?  Dysport  is a type A botulinum toxin that was approved  by the FDA  for the improvement of lines in the glabellar complex (the “frown lines”). The main difference between the two is how they are purified.  Botox is purified by repeated precipitation and redissolution,  and Dysport is done by utilization of a column separation method. Because of the differences in this purification process,  it affected how the protein complex that surrounds the neurotoxin (the protein “coat”) in Dysport acts.  Essentially,  the active part of Dysport and Botox are housed in a protein coat,  and the purification process affected how these coats “shed” once introduced into a muscle. I like to compare them to regular M&M’s and Peanut M&Ms.  In this sense,  Dysport acts kind of like the regular M&M, whose coat is much thinner,  and Botox similar to the thicker peanut M&M.  Because of the differences in these coats,  Dysport acts a little faster,  and spreads out a little more to surrounding areas than does Botox.  Also,  there’s a difference in reconstitution.  One vial of Botox yields 100 Units when reconstituted in 2.5 mL of normal saline (Dose= 4 Units per 0.1mL), while  2.5 mL normal saline yields 300 units of Dysport per vial (Dose= 10 Units per 0.08 cc mL).   While this may seem as if you get more bang for your buck with Dysport,  this isn’t necessarily so,  considering the fact that 1 Unit of Botox will work the same as 2.5 – 3 Units of Dysport. 

So which is better?  There’s really no telling which toxin is superior to the other.  After all,  both practically work the same way.  I guess it depends on the area that needs to be treated.  For areas like crow’s feet and upper forehead lines should be treated with something that spreads out a little more for greater softening effect,  so Dysport might be a the winner here.  On the other hand,  pinpoint areas such as “smoker’s lips” or areas nearer to the brow line might work better with Botox because you may need more precision.  Personally,  I think this wrinkle-fighting war is a stalemate,  as both Dysport and Botox are expected to work together to achieve frown-less faces everywhere.




Credits:
Principles of Cosmetic Dermatology.  Baumann, 2009.
Botox vs. Dysport IAPAM Discussion
. www.iapam.com


The following two tabs change content below.
Cristal

Cristal

Online Editor, Beauty Writer at Beauty-Goodies
As a New York City-based registered nurse with backgrounds in pharmacology, medical research, medical spa aesthetics, and cosmetic dermatology, Cristal became interested in the ways people go about achieving beauty. When she's not working full-time at Cornell Medical Center or performing aesthetic treatments at a midtown NYC medical spa, she daylights as a beauty writer, and has a penchant for scoring sample sale treasures, bellydancing, playing dress-up, and of course, chatting about beauty goodies.
Cristal

Latest posts by Cristal (see all)

14 thoughts on “Battle of the Botox: Botox Cosmetic™ vs. Dysport®

  1. Gauwain

    I seem to be having a problem , subscribing to your RSS feed. It comes up with error 451. Let me know if its a known error or if its just me . Ive tried opera and IE. Im using Eset Firewall and im not sure how to turn it off . Im not that good with PCs. Ill bookmark your site and see if you have responded. all the best

  2. Aurelia Morando

    So Great! I need some infos in this post for my rapport de stage. Can i have your contact please? I need your permission to quote it :D. Anyway, That’s great job. Keep going.

  3. Tonya Solesbee

    So Great! I need some infos in this post for my rapport de stage. Can i have your contact please? I need your permission to quote it :D. Anyway, That’s great job. Keep going.

  4. Jessie Goulden

    So Great! I need some infos in this post for my rapport de stage. Can i have your contact please? I need your permission to quote it :D. Anyway, That’s great job. Keep going.

  5. Hansford14

    Danke für dies Waren, dies Bereich hat mich interessé wahrhaft viel. Grace hinein dies Artikel habe ich beste Sachen entscheident gelernt, gute ich in keiner weise kannte. Danke, bravo sowie Respekt.

  6. CristalCristal Post author

    Lipo Risks, I completely agree that there are many people who have difficulty achieving the “perfect” look. I agree that people should be able to have the freedom to do what they want with themselves, however, it’s important for them to make and informed decision before doing so. Thanks for the comment!

  7. dubturbo

    Helpful information. Fortunate me I found your website accidentally, and I am surprised why this coincidence didn’t took place earlier! I bookmarked it.

  8. cosmetic care

    That’s great! I really enjoyed your blog throughout all the time I have spent on it! Thanks for sharing such an informative with us. I am really acknowledged by the content provided by you on this blog and I hope to see some more achievements from your blog that’s why I am going to bookmark it right now.
    botox cosmetic

Leave a Reply

Your email address will not be published. Required fields are marked *